Abstract
Aim To assess the current clinical evidence of the effectiveness of Da-Cheng-Qi Decoction (DCQD) for the treatment of Postoperative gastrointestinal dysfunction (PGD). Methods Randomized controlled trails (RCTs) of Da-Cheng-Qi Decoction (DCQD) to PGD were searched from available major electronic databases to September 2016. The intervention must be a modified DCQD or DCQD integrated to Western Medicine (WM) compared with WM or placebo or blank. The main outcome index was clinical effectiveness and improvement of major symptoms. Data extraction, data analysis, and methodological quality assessment are conducted according to the Cochrane Handbook for Systematic Review of Interventions, version 5.0.2. RevMan 5.3 software was applied to our data analyses. Results Seven RCTs involving 494 participants were recruited and identified. The methodological quality of all trials were assessed and generally of low-level. Those studies were published between 2004 and 2013. All 7 studies which used herbals (modified DCQD) integrate WM in test group compared with WM as the intervention and only one study (Sunyouxu 2013) integrates placebo to Western Medicine as the control group intervention. The treatment course was 1 week to 2 weeks. Evaluation of intervention effectiveness consists of the clinical effective rate indicator and the PGD symptoms indicator including time of borborygmus, time of gastrointestinal exhaust, and time of defecate. The clinical effectiveness results are beneficial to the test group. Conclusion DCQD could improve PGD symptoms and promotion clinical effectiveness.
Highlights
We passed by 68 papers through screening the title and the abstract due to the non-Randomized controlled trails (RCTs) but case reports, clinical observations, animal experimental studies, mechanism research studies, repetition papers, diabetic gastroparesis, and literature reviews
The functional gastrointestinal disorders of postoperative of Postsurgical gastrointestinal dysfunction (PGD) may lead to the digestive system not working for a few days, abdominal dissension, constipation, and so on
It is caused by intraoperative wound traction or lack of visceral perfusion which have been considered as one of the most
Summary
Postsurgical gastrointestinal dysfunction (PGD) or postsurgical gastroparesis syndrome (PGS) is a serious generally nonmechanical obstruction complication of abdomens postoperative and it is a functional disorder characteristic as delayed gastric emptying [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17] It often happens after a few days or weeks or even years of surgery. Clinical practices often applied taken abrosia, gastrointestinal decompression, and choline drug resistance avoiding treating PGD/PGS but the efficacy was not guaranteed and remains of high recurrence rate [4], finding that alternative drugs to show efficacy for PGD/PGS are necessary
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