Abstract
Schizophrenia patients are susceptible to lower bone mineral density (BMD). However, studies exploring the genetic effects are lacking. Genes that affect the activity of antipsychotics may be associated with BMD, particularly in patients receiving long-term antipsychotic treatment. We aimed to explore the relationship between the dopamine receptor D2 (DRD2) gene Taq1A (rs1800497) polymorphism and BMD in chronic schizophrenia patients. We recruited schizophrenia patients (n = 47) and healthy controls (n = 39) from a medical center in Taiwan and collected data that may affect BMD. Patients’ BMD was measured by dual-energy X-ray absorptiometer (DEXA). DRD2 rs1800497 was genotyped through polymerase chain reaction–Restriction Fragment Length Polymorphism (PCR–RFLP). Among all participants, subjects with DRD2 rs1800497(T;T) allele had lower DEXA T score and DEXA Z score compared to those with rs1800497(C;T) and rs1800497(C;C) alleles (p = 0.008, 0.003, respectively). In schizophrenia patients, subjects with rs1800497(T;T) allele also had lower DEXA Z score compared to the other two alleles (p = 0.045). Our findings suggest that individuals with the DRD2 rs1800497(T;T) had lower BMD than those with the rs1800497(C;T) and rs1800497(C;C) genotypes. Therefore, genes should be considered as one of the risk factors of lower BMD.
Highlights
With an increasingly ageing society, decreased bone mineral density (BMD) is an issue worthy of more attention
Some studies found that dopamine receptor D2 (DRD2) gene was involved in genetic susceptibility to posttraumatic stress disorder, risk factors associated with smoking and schizophrenia[15,16,17]
We further examined the effect of rs1800497 genotypes, gender and prolactin level on DEXAZ score using multiple linear regression model
Summary
With an increasingly ageing society, decreased bone mineral density (BMD) is an issue worthy of more attention. Schizophrenia is among the most critical psychiatric diseases in the world These patients have markedly premature mortality and a variety of physical comorbidities. The direct mechanism is through the pathway of osteoblast cells, while the indirect one is through the suppression of gonadal hormone levels via the hypothalamic–pituitary–gonadal a xis[9] The etiology of both low bone mineral density (LBMD) and osteoporosis is multi-faceted, and lifestyle, psychotic symptoms, medication use, alcohol consumption, and genes may all be r elated[10,11]. Some studies found that dopamine receptor D2 (DRD2) gene was involved in genetic susceptibility to posttraumatic stress disorder, risk factors associated with smoking and schizophrenia[15,16,17]. In this study, we aimed to clarify the relationship between DRD2 rs1800497 gene and bone mineral density
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