Abstract
Two species of the fungus Cephalosporium form increased amounts of cephalosporin N (synnematin B) when grown in natural media supplemented with D-methionine. Only those derivatives of methionine that were easily converted into methionine were effective in increasing the accumulation of cephalosporin N. Neither of the two adjacent homologs of methionine increased the amount of biologically active penicillin formed. No evidence was obtained for the production of a penicillin different from cephalosporin N. d-Methionine is presumed to be effective in increasing the concentration of cephalosporin N by reason of its incorporation into the terminal portion of the d-α-aminoadipic acid side chain of the penicillin molecule.
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