D-Galactosamine induced hepatitis in the rabbit: Effect on lecithin:cholesterol acyltransferase activity, plasma lipid transfer protein activity and high density lipoproteins

Abstract

1. 1. Hepatitis was induced in rabbits by a single intraperitoneal injection of d(+)-galactosamine-HCl (750 mg/kg body wt). 2. 2. Plasma lecithin:cholesterol acyltransferase activity fell to 5% and lipid transfer protein activity to 50% of control values 48 hr after injection. 3. 3. Discoid high density lipoprotein began to appear in plasma of treated rabbits 36 hr after injection, along with populations of high density lipoprotein (HDL) which were both smaller (radius 3.7 nm) and larger (radius 5.9 nm) than the original HDL population (radius 4.8 nm).