Abstract
Coronavirus infectious disease 2019 (COVID-19) infections, a highly coagulative and in-flammatory state, predispose patients to arterial and venous thrombotic events due to platelet activation,
 endothelial dysfunction, and stasis. There are several reasons why elevated levels of D-dimer indicatethe severity of the disease. This review paper aims to revise the significance of D-dimer levels in thecovid-19. Thus, according to the studies, the increase in D-dimer level was significantly associated with
 the severity of the disease's course and the mortality rate. Moreover, in the case of mortality of hospi-talized patients, a very high level of D-dimer is detected, which confirms that D-dimer can be used as a
 valuable biomarker for evaluating clinical outcomes in patients with Covid-19.
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