Abstract
The administration of methamphetamine caused an increase of c- fos mRNA in the striatum of the mouse. A systemic injection of the δ-opioid receptor agonist, [ d-Ala 2, d-Leu 5]enkephalin (DADLE), attenuated the c- fos mRNA increase induced by methamphetamine. These results suggest that endogenous δ-opioid peptides might counteract certain genomic influences exerted by psychostimulants such as methamphetamine.
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