Abstract
Quantitative autoradiography was used to determine the distribution of D 3 receptors in rat spinal cord and compare it with the distribution of D 1-like and D 2 (and D 4) receptors. [ 3H]PD 128907-labeled D 3 sites were observed in roughly 6-fold lower density than [ 3H]spiperone-labeled D 2 (D 4) sites and 60-fold lower density than [ 3H]SCH 23390-labeled D 1-like sites. Highest densities of D 3 binding were observed in the superficial layers of the dorsal horn at cervical and lumbar levels followed by the pars centralis and dorsal horn. Lowest densities of D 3 sites were detected in the ventral horn. These observations suggest that spinal D 3 receptors may play a role in sensory and/or motor function or contribute to the pharmacological effects of dopaminergic drugs.
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