Abstract
Dopamine and dopamine receptor agonists (0.1 microM-10 mM) evoked in a concentration-dependent manner, calcium-dependent release of [3H]acetylcholine from the rabbit retina labeled in vitro with [3H]choline. This stimulatory effect of dopamine was antagonized by SCH23390 and by alpha-flupenthixol, but not by S-sulpiride or propranolol. Increases in intracellular cyclic AMP by forskolin, 3-isobutyl-1-methylxanthine and 8-bromo-cyclic AMP also evoked calcium-dependent release of [3H]acetylcholine. These results indicate that activation of a receptor with the biochemical and pharmacological characteristics of a D1-dopamine receptor mediates calcium-dependent release of acetylcholine from rabbit retina, possibly through a cyclic AMP-dependent process.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.