D-ß-hydroxybutyrate: an anti-aging ketone body

Clare Edwards,Neil Copes,Patrick C Bradshaw

doi:10.18632/oncotarget.3423

Abstract

D-ß-hydroxybutyrate: an anti-aging ketone body

Highlights

SSHB levels have been shown to increase to roughly 1-2 mM levels in the plasma during fasting or to 0.6 mM during calorie restriction (CR) [2], a 20%-40% lowering of caloric intake that consistently extends lifespan and protects against disease [4]
We have recently shown that administering ßHB to C. elegans nematodes extended lifespan and delayed proteotoxicity and glucose toxicity [5]
Even though the protective effects of ßHB have already been shown in rodent disease models, this was the first report to identify ßHB as a positive modulator of lifespan in wild-type animals. ßHB extended the lifespan of C. elegans, but this lifespan extension was almost completely eliminated in worms where either the histone deacetylase (HDAC) hda-2 or the HDAC hda-3 was knocked down

Summary

Introduction

SSHB levels have been shown to increase to roughly 1-2 mM levels in the plasma during fasting or to 0.6 mM during calorie restriction (CR) [2], a 20%-40% lowering of caloric intake that consistently extends lifespan and protects against disease [4]. We have recently shown that administering ßHB to C. elegans nematodes extended lifespan and delayed proteotoxicity and glucose toxicity [5]. D-ßHB, but not L-ßHB, extended C. elegans lifespan in a sirtuin SIR-2.1 and AMP kinase-dependent manner that required the stress-responsive transcription factors DAF-

Results

Conclusion