Abstract
The Triple Negative “Basal-like” breast cancer (TNBL) tumours have a high proliferative capacity and develop a resistance phenotype associated with metastases. However, the management of TNBL carcinomas is still not standardized. Among the promising trails, gold nanoparticles could be a relevant tool for the development of a targeted treatment for this breast cancer subtype in monotherapy, associated and/or conjugated with other drugs. In this work, we report the cytotoxicity impact of gold nanoparticles wrapped in Poly-Ethylene Glycol (PEG) on the TNBL HCC-1937 breast cancer cell line. PEG-coated gold nanoparticles (PEG-Au NPs) were synthesized by a two-step method using a reduction process followed by a post-functionalization called PEGylation. PEG-Au NPs were characterized using transmission electron microscopy and X-ray diffraction. The gold content of the samples was determined using atomic absorption spectrometer. The cytotoxicity tests were performed using Sulforhodamine B survival test and resazurin viability test. PEG-Au NPs impact analysis on HCC1937 TNBL cell line showed a clear toxic action of type dose dependent and at long term. These PEGylated gold nanoparticles present a promising tool for the development of tumor-specific radiosensitizing vectors, with or without the association of other treatment strategies.
Highlights
Gold nanoparticles (GNPs) are promising candidates in the field of medicine for the treatment of illnesses such as Alzheimer’s [1], vascular [2], skin [3], sclerosis [4] and cancer [5]
We report the cytotoxicity impact of gold nanoparticles wrapped in Poly-Ethylene Glycol (PEG) on the Triple Negative “Basal-like” breast cancer (TNBL) HCC-1937 breast cancer cell line
These works were focused on the cytotoxicity impact of gold nanoparticles wrapped in Poly-Ethylene Glycol (PEG), on the TNBL HCC-1937 breast cancer cell line
Summary
Gold nanoparticles (GNPs) are promising candidates in the field of medicine for the treatment of illnesses such as Alzheimer’s [1], vascular [2], skin [3], sclerosis [4] and cancer [5]. The use of gold nanoparticles to try to cure cancer is a very active field of research With this nanomedicine strategy, gold nanoparticles are defined to target tumorous cells and minimize side effects [26] [27], to enhance conventional therapies [28] [29] or to develop new diagnostic and therapeutic devices [30] [31]. The management of TNBL carcinomas is still not standardized Among these promising trails, gold nanoparticles could be a relevant tool for the development of a targeted treatment for this breast cancer subtype in monotherapy, associated and/or conjugated with other drugs [40]. These works were focused on the cytotoxicity impact of gold nanoparticles wrapped in Poly-Ethylene Glycol (PEG), on the TNBL HCC-1937 breast cancer cell line
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