Abstract
The cytotoxicity of selected metal-containing dithiocarbamate fungicides was determined using Chinese hamster ovary cells (CHO-K1) in culture. Bis(dimethylthiocarbamoyl)disulfide (thiram) and ferric dimethyldithiocarbamate (ferbam) were more toxic, having LC50 values of 5 × 10 −7 and 7 × 10 −7 m, respectively, whereas manganese ethylene bisdithiocarbamate (maneb) and zinc ethylene bisdithiocarbamate (zineb) were less toxic, having LC50 values of 3 × 10 −6 and 6 × 10 −6 m, respectively. Analysis of the data using “target theory” showed that ferbam, thiram, maneb, and zineb have a common hit number. These studies suggest that these fungicides have a common mechanism of toxicity.
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