Abstract
Objective To investigate the cytotoxicity of the crude ethanol extract of the rhizome of Zingiber zerumbet ( Z. zerumbet) (L) Smith. and Curcuma zedoaria ( C. zedoaria) Rosc. against Artemia salina Leach Methods Fresh rhizomes of Z. zerumbet (L) Smith. and C. zedoaria Rosc. were extracted separately in cold with ethanol (2.5 L) and after concentration a brownish syrupy suspension of ethanol extracts of Z. zerumbet (L) Smith. and C. zedoaria Rosc. was obtained. The cytotoxic effect of the crude ethanol extracts of both plants was determined by brine shrimp lethality bioassay Results Crude ethanol extracts of the rhizome of Z. zerumbet (L) Smith. showed the highest cytotoxicity (LC 50 was 1.24 μg/mL) against brine shrimp nauplii as compared with C. zedoaria Rosc. (LC 50 was 33.593 μg/mL) after 24 h of exposure. Conclusions It can be concluded that the rhizome of Z. zerumbet (L) Smith. and C. zedoaria Rosc. can be used as a source of cytotoxic agent.
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