Abstract
The reaction between bromo pentacarbonyl manganese(I) and two equivalents of 1-(chloromethyl)-1H-benzotriazole (BTZ-CH2Cl) afforded visible-light induced carbon monoxide releasing molecule of the general formula, fac-[MnBr(CO)3(BTZ-CH2Cl)2]. The solvatochromism, dark-stability and photolysis profile of the titled complex was examined in organic solvents with various hydrogen-bonding propensities, coordinating capabilities, and solvent polarities as well as in the presence of proteins. The number of CO equivalents released from the titled complex upon the exposure to a 468 nm LED light was determined using myoglobin assay. The titled complex displayed selective cytotoxicity towards human acute monocytic leukaemia in the dark without causing any harmful effect to the normal mice bone marrow stromal cells.
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