Cytotoxicity of Fe2+, Cu2+, and Ni2+ metal complexes of thiosemicarbazide Schiff bases with dibenzalcyclohexanone & Di-o-bromobenzalcyclohexanone

Abstract

The work included the synthesis and characterization of two ketones (chalcones) through the reaction of cyclohexanone with benzaldehyde in the presence of a strong base, as well as ketones were prepared replaced with bromine in the ortho position from the reaction of brominated benzaldehyde in the ortho site with cyclohexanone . The first ligand prepared through the reaction of the thiosemicarbazide compound with dibenzalcyclohexanone, while the second ligand was prepared by reacting di-o-bromobenzalcyclohexanone. The resulting ligands are bi-dentate ligands that can bind to transition metal ions in a molar ratio (ligand:metal) 2:1. As mononuclear complexes were prepared through the reaction of these ligands with the divalent metallic elements under study, which are copper(II), iron(II) and nickel(II). The novel complexes have been characterized by 1H&13C-NMR, (Mass Spectra), magnetic susceptibility and molar conductivity. And through spectroscopic studies and magnetic susceptibility, the geometry of the prepared complexes were suggested. The iron and copper complexes are paramagnetic complexes, and the magnetic moment values are within the range of the distorted tetrahedral. While for the nickel complexes, they are diamagnetic complexes, and the magnetic moment values are within the range of the distorted square planar shape.