Abstract
Ionic Liquid-based Microwave-Assisted Extraction (Il-MAE) of Oxyresveratrol from Morus alba RootsMazaya Fadhila, Abdul Mun’im, Mahdi Jufri
Highlights
Cancer is the second reason of death worldwide
its extract killed 50% of the cells (IC50) value determination of plants extract in P19 cell line In this study, the cytotoxic activity of methanol extracts of 4 plants were determined using MTT assay in P19 cell line exposed to 10-2560 μg/ml of extracts at three incubation period of 48, 96 and 144 and IC50 values were determined
It was demonstrated that its extract killed 50% of the cells (IC50) at a lower concentration in three incubation period when compared to other plant extract tested (Fig. 2)
Summary
Conventional therapies for cancer include surgery, cytotoxic chemotherapy, immunotherapy and radiation therapy which are used as a single or combinatorial therapy have some side effects. In the last decades of the 20th century, the cancer stem cell hypothesis has attracted much attention. According to this concept, CSCs as rare sub-population of tumor cells have been recognized with some similarity to normal stem cells such as capacity of self-renewal and differentiation. CSCs as rare sub-population of tumor cells have been recognized with some similarity to normal stem cells such as capacity of self-renewal and differentiation These kinds of cancer cells are resistant to apoptosis and have long lifetime. Some properties of CSCs such as cell cycle quiescence, increased
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