Abstract
Background: The species from the genus Garcinia has long been used as traditional medicine for cancer treatment. Objective: To analyze the phytochemical contents and assess the cytotoxic effects of pericarp extracts of Garcinia forbesii King against MCF-7 breast cancer cells and HepG2 liver cancer cells. Materials and Methods: The phytochemical contents were analyzed using the thin-layer chromatography and the cytotoxic activity was assessed using the MTT assay method. Results: Phytochemical screening showed the presence of alkaloids, flavonoids, terpenoids and polyphenols. The cytotoxic activities of n-hexane, DCM and ethyl acetate extracts on MCF-7 cells were shown with IC50 103.605±2.3410 μg/ mL, 397.609±28.0534 μg/mL and 1,518.301±68.6379 μg/mL respectively, while the IC50 on HepG2 cells were 79.798±1.2261 μg/mL, 83.230±4.2557 μg/mL and 671.875±94.3338 μg/mL respectively. Conclusion: The n-hexane, DCM and ethyl acetate extracts from pericarps of G. forbesii King have cytotoxic activities against MCF-7 and HepG2 cancer cells, therefore, it has the potential to be developed as an anticancer.
Highlights
According to the World Health Organization data in 2004, the top five cancer occurrences in the world were lung cancer, breast cancer, colon cancer, stomach cancer and liver cancer
The cytotoxic activities of n-hexane, DCM and ethyl acetate extracts on MCF-7 cells were shown with IC50 103.605±2.3410 μg/ mL, 397.609±28.0534 μg/mL and 1,518.301±68.6379 μg/mL respectively, while the IC50 on HepG2 cells were 79.798±1.2261 μg/mL, 83.230±4.2557 μg/mL and 671.875±94.3338 μg/mL respectively
The n-hexane, DCM and ethyl acetate extracts from pericarps of G. forbesii King have cytotoxic activities against MCF-7 and HepG2 cancer cells, it has the potential to be developed as an anticancer
Summary
According to the World Health Organization data in 2004, the top five cancer occurrences in the world were lung cancer, breast cancer, colon cancer, stomach cancer and liver cancer. While the number of deaths from cancer increased from 7.6 million people in 2008 to 8.2 million in 2012. Liver cancer incidences is on the second highest after lung cancer, with 14.5% deaths[2]. Objective: To analyze the phytochemical contents and assess the cytotoxic effects of pericarp extracts of Garcinia forbesii King against MCF-7 breast cancer cells and HepG2 liver cancer cells. The cytotoxic activities of n-hexane, DCM and ethyl acetate extracts on MCF-7 cells were shown with IC50 103.605±2.3410 μg/ mL, 397.609±28.0534 μg/mL and 1,518.301±68.6379 μg/mL respectively, while the IC50 on HepG2 cells were 79.798±1.2261 μg/mL, 83.230±4.2557 μg/mL and 671.875±94.3338 μg/mL respectively. Conclusion: The n-hexane, DCM and ethyl acetate extracts from pericarps of G. forbesii King have cytotoxic activities against MCF-7 and HepG2 cancer cells, it has the potential to be developed as an anticancer.
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