Abstract
Screening of the dichloromethane partition of the ethanol extract of over 100 Puerto Rican plants has been achieved resulting in 29 extracts active in the brine shrimp lethality assay (LC 50 < 1000 µg/ml). These were subjected to further biotesting in two cytotoxicity tests: against HeLa and CHO cells. The plants active in both cytotoxicity assays were: Annona glabra L., Simarouba tulae Urban, Tithonia diversifolia (Hemsl.) A. Gray, Dendropanax arboreus (L.) Decne. & Planch., Piper jacquemontianum Kunth, Annona montana Mafad, and Polygala hecatantha Urban. The plants selectively active in the HeLa assay were Cassine xylocarpa Vent. and Capparis flexuosa (L.) L.; in the CHO assay, Amyris elemifera L.
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