Abstract
This work features design and syntheses of four mononuclear Pt(II) complexes [Pt(L1–H)Cl]; 1, [Pt(L2–H)Cl]; 2, [Pt(L3–H)Cl]; 3, and [Pt(L4–H)Cl]; 4, which were judiciously prepared by tethering with a ONSe donor core of Schiff base ligands (L1–L4). The complexes were fully characterized by IR, NMR spectra, elemental analysis and single crystal X-ray diffraction (sc-XRD) analysis. Notably, cytotoxicity profile of these structurally amended complexes against human breast cancer cell line (MCF-7) and mouse model fibroblast cells (NIH-3T3) cell lines revealed remarkable anticancer activity and selectivity based on their structural activity.
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