Abstract
The chemical composition of hydrodistilled essential oil from the aerial flowering parts of D. surmandinum was analyzed for the first time by GC and GC-MS. Monoterpenoids including oxygenated and hydrocarbons comprising 63.4 and 33.9% were the principal compound groups of the essential oil, respectively. In total, 25 constituents accounting for 97.8% of the oil were identified [1]. Perilla aldehyde (54.3%) and limonene (30.1%) were characterized as the main components. In addition, our results indicated that the essential oil of D. surmandinum (5–100µg/ml) possesses a marked antioxidant and radical scavenging activity using different model systems including Trolox equivalent antioxidant capacity, β-carotene-linoleic acid blenching and 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH) assays [2]. The cytotoxicity activity was also carried out using the MTT assay [3]. Results showed that the essential oil of D. surmandinum has a good cytotoxic activity against Human breast adenocarcinoma cell line (MCF-7) and Human erythromyeloblastoid leukemia cell line (K562) with an IC50 value of 14 and 16µg/ml, respectively. However, the cytotoxic potential of D. surmandinum essential oil against Rat adrenal pheochromocytoma cell line (PC 12) was weak (IC50 of >100µg/ml).
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