Abstract
The aerial parts of Salvia mirzayaniiwere collected at full flowering stage from Geno, Tange Zagh, Qotb Abad, Roodan of Hormozgan province, Iran. The essential oil was isolated by hydrodistillation and analyzed by combination of capillary GC and GC-MS. 21 components were identified, representing 88.0% of the total oil. Spathulenol (23.1%), linalool (12.0%), 1,8-cineole (8.5%), α-cadinol (6.2%), linalyl acetate (6.0%), terpinenyl acetate (5.5%), cubenol (4.8%), aromadendrone (3.5% ) and thymol (1.0%) were the main components. The in vitro antimicrobial activity of the essential oil of S. mirzayaniiwas studied against eight Gram-positive and Gram-negative bacteria (Bacillus subtilis, B. pumulis, Enterococcus faecalis, Staphylococcus aureus, S. epidermidis, Escherichia coli, Pseudomonas aeruginosa and Klebsiellapneumoniae) and three fungi (Candida albicans, Saccharomyces cerevisiae and Aspergillus niger).The results of the antimicrobial activities of the essential oil according to the disk diffusion method and MIC values indicated that the oil exhibited high antimicrobial activity against Gram positive bacteria and low activity against the Gram negative organisms. Cytotoxicity assay showed HFSF and Vero cell line was sensitive to S. mirzayani essential oil.
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