Abstract
This study comprehensively characterized LAPONITE® and evaluated its cytotoxic and genotoxic effects on rat adipose-derived stem cells (ADSCs). Chemical analyses included Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. Cytotoxic screening using the Artemia salina lethality test indicated low toxicity. ADSCs exhibited mesenchymal stem cell chracteristics. LAPONITE® demonstrated osteogenic induction capability. MTT assays revealed increased cell viability across concentrations and exposure times. The comet assay for genotoxicity showed no significant differences in damage index between experimental groups, except for a distinction in the frequency of damage between LAPONITE® concentrations at the longest exposure time. This comprehensive assessment provides valuable insights into the safety and potential applications of LAPONITE® in regenerative medicine.
Published Version
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