Abstract
It is of interest to document the cytotoxicity and anti microbial analysis of silver and graphene oxide nanoparticles. The plant extracts from Andrographis paniculata and Ocimum sanctum Linn were used as reducing agent. The nanoparticles were characterized using UV-visible spectroscopy, FT-IR, XRD and TEM. The antimicrobial activity was completed for oral pathogens. Brine Shrimp Lethality assay was conducted for cytotoxicity. Thus, we show that silver and graphene oxide bio based nanoparticles have antimicrobial activity with minimum cytotoxic effects.
Highlights
Nanoparticles finds application in Biomedicine [1]
Wierzbicki et al assessed the cytotoxic effect of graphene oxide silver nanoparticle composite and found the combination seems to be less toxic when compared to silver nanoparticles used alone [12]
The present study appear to be first of its kind as the combination of leaf extracts of Andrographis paniculata and Ocimum sanctum Linn to synthesise Silver and Graphene oxide nanoparticles have not been reported previously in the literature
Summary
Nanoparticles finds application in Biomedicine [1]. They are often produced using physical and chemical methods [2]. These molecules are produced using biological methods using plants, fungi and bacteria [3]. Silver nanoparticles have attracted attention as they have favorable electrical conductivity, chemical stability and antibacterial activity [4]. Andrographis paniculata is known for its potent antiinflammatory formulations [6]. We synthesised Silver and graphene oxide nanoparticles using leaf extract of Andrographis paniculata and Ocimum sanctum Linn. It is of interest to document the cytotoxicity and anti microbial analysis of silver and graphene oxide nanoparticles
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