Cytotoxic withanolide constituents of Physalis longifolia

Abstract

Twenty three withanolides including sixteen new 1-16 (named as withalongolides A-P) were isolated from the aerial parts of Physalis longifolia Nutt. (Solanaceae). Their structures were elucidated through spectroscopic techniques including X-ray crystallography (for 1-3, 6, and 15). Nine withanolides and six derivatives showed potent cytotoxicity against a panel of cells (JMAR, MDA-1986, B16F10, DR081–1, SKMEL-28, Hs578T, and MRC-5) with IC50 values in the range of 0.067 ˜ 17.4µM.