Abstract
• Nine triterpenoids were isolated from the bark and twigs of Schima crenata . • Structures of four new compounds were elucidated by spectroscopic analysis. • Compounds were evaluated for their cytotoxicity against three tumor cell lines. • Compounds 4 , 8 , and 9 showed potent cytotoxic activities. Four new triterpenoids ( 1 - 4 ), along with five known triterpenoids ( 5 - 9 ), were isolated from the bark and twigs of Schima crenata . Their structures were elucidated by the use of extensive spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Most of the compounds were evaluated for their cytotoxicity against the A375, A549, and LoVo cancer cell lines. Compounds 4 , 8 , and 9 displayed inhibitory activity against three tumor cell lines with IC 50 values ranging from 3.63 ± 1.86–8.64 ± 1.55 μM, even stronger than the positive control cisplatin.
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