Abstract
AbstractCytotoxic T cell (CTL) responses to cells coupled with high or low doses of the hapten 3‐(p‐sulfophenyldiazo)‐4‐hydroxyphenyl acetic acid (SP) were studied. CTL responses to densely coupled cells were obtained with all mouse strains tested. Only mice carrying the Kk allele responded to sparsely coupled cells. Mice expressing I‐Akbut not Kk were nonresponders. (Responder × nonresponder) F1 hybrids responded in vitro to sparsely coupled cells from responder but not from nonresponder mice. However, responder mice could be cross‐primed in vivo with SP‐coupled cells from nonresponder mice. CTL responding to sparsely coupled cells were restricted to Kk. Cross‐reactive lysis of target cells not carrying the Kk allele was dependent on the hapten density and the H‐2 haplotype carried by the target cells.
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