Abstract
Bovine tuberculosis is a chronic mycobacterial infection that impinges on a wide range of mammals, including man, cattle, deer, pigs and carnivores. The present investigationdeals with the anti-mycobacterial potential of Andrographolide againstMycobacterium bovis, commonly known as bovine tuberculosis.The bioactive compound andrographolide was isolated from the leavesof Andrographis paniculata. Employing different techniques viz. zone of inhibition, disc diffusion and turbidometric method,the MIC of andrographolide was found to be vacillating between 100 and 11.11µg/ml against the test organism (Garg& Shrivastava, 2013). The results suggested andrographolide compound to be a potent antibiotic against M. bovis and its inhibitory effect is on par with standard drugs like isoniazid and fluoroquinolones. Keywords:Andrographolide,Andrographispaniculata, Bovine tuberculosis,Mycobacterium bovis.
Highlights
Mycobacterium bovis is part of the Mycobacterium tuberculosis complex and is responsible for tuberculosis infections inseveral animal species, including human beings (Garnieret. al. 2003)
Thoughepisodes of mycobacterial contagion are not infrequent, yet our information,with reference torelative virulence ofM. tuberculosis and M. bovis in man, post-infection possibilities, immunological consequences, occurrence of man-to-man transmission andits further spread to cattle,is still inadequate (Grange, 2001)
Notwithstanding the fact that plants are potential source of chemical constituents with enormous propensity to synthesize a variety of structurally diverse bioactive compounds, very little documentation has been made regarding the cure of mycobacterial tuberculosis
Summary
Mycobacterium bovis is part of the Mycobacterium tuberculosis complex and is responsible for tuberculosis infections inseveral animal species, including human beings (Garnieret. al. 2003). Unpasteurized dairy products have been reported to be thelargest source of infectivity. Tuberculosis and M. bovis in man, post-infection possibilities, immunological consequences, occurrence of man-to-man transmission andits further spread to cattle,is still inadequate (Grange, 2001). Notwithstanding the fact that plants are potential source of chemical constituents with enormous propensity to synthesize a variety of structurally diverse bioactive compounds, very little documentation has been made regarding the cure of mycobacterial tuberculosis. Andrographispaniculatais one of the plant resources containing bioactive compound - andrographolide and has been used in conventional Siddha and Ayurvedic system of meditation for multiple clinical applications since medieval times (Ahmed &Aswami , 1993). The present study is aimed to endorse ‘andrographolide’ as an effective bioactive compound and its therapeutic application in treatment of bovine tuberculosis
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