Abstract
Four new compounds, including two new polyketides, heterocornols M and N (1, 2), and a pair of epimers, heterocornols O and P (3, 4), were isolated from the fermentation broth of the marine sponge-derived fungus Pestalotiopsis heterocornis XWS03F09, together with three known compounds (5–7). The new chemical structures were established on the basis of a spectroscopic analysis, optical rotation, experimental and calculated electronic circular dichroism (ECD). All of the compounds (1–7) were evaluated for their cytotoxic activities, and heterocornols M-P (1–4) exhibited cytotoxicities against four human cancer cell lines with IC50 values of 20.4–94.2 μM.
Highlights
Marine-derived microorganisms have been attracting widespread attention as a huge resource for the discovery of bioactive natural products [1]
In order to obtain more new bioactive natural products from species of this genus, a strain of Pestalotiopsis heterocornis was refermented in the same culture medium
The chemical investigation of this fungus led to the isolation and identification of four new polyketide derivatives, heterocornols M-P (1–4), together with three known compounds, (R)–3–Hydroxy–1–[(R)–4–hydroxy–1,3–dihydroisobenzofuran–1–yl]butan–2–one
Summary
Marine-derived microorganisms have been attracting widespread attention as a huge resource for the discovery of bioactive natural products [1]. We reported sixteen new compounds including heterocornols A-L [11], pestaloisocoumarins A and B, isopolisin B, and pestalotiol A [12], from the fungus. Pestalotiopsis heterocornis (XWS03F09), which have been shown to exhibit cytotoxic and antibacterial activities in vitro. In order to obtain more new bioactive natural products from species of this genus, a strain of Pestalotiopsis heterocornis was refermented in the same culture medium. The chemical investigation of this fungus led to the isolation and identification of four new polyketide derivatives, heterocornols M-P (1–4), together with three known compounds, (R)–3–Hydroxy–1–[(R)–4–hydroxy–1,3–dihydroisobenzofuran–1–yl]butan–2–one (5) [13], (R)–3–Hydroxy–1–[(S)–4–hydroxy–1,3–dihydroisobenzofuran–1–yl]butan–2–one (6) [13], 4,8–dihydroxy–1–tetralone (7) [14] (Figure 1). The details of the isolation, structures elucidation, and cytotoxic activity against the human cancer cell lines of these compounds are reported
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
