Cytotoxic polyketides from Annona densicoma (annonaceae): 10,13-trans-13,14-erythro-densicomacin, 10,13-trans-13,14-threo-densicomacin, and 8-hydroxyannonacin

Abstract

Three new linear polyketides, 10,13-trans-13,14-erythro-densicomacin (1), 10,13-trans-13,14-threo-densicomacin (2), and 8-hydroxyannonacin (3), and a known polyketide goniothalamicin were isolated from the stem bark of the Peruvian plant Annona densicoma Mart (Annonaceae). Their structures were elucidated on the basis of UV, IR, 1 H and 13 C NMR, and mass spectrometry data of the natural compounds and their derivatives. These polyketides are cytotoxic against human tumor cells in culture