Abstract
Two new polyketide natural products, globosuxanthone F (1), and 2′-hydroxy bisdechlorogeodin (2), were isolated from the fungus Pleosporales sp. NBUF144, which was derived from a 62 m deep Chalinidae family sponge together with four known metabolites, 3,4-dihydroglobosuxanthone A (3), 8-hydroxy-3-methylxanthone-1-carboxylate (4), crosphaeropsone C (5), and 4-megastigmen-3,9-dione (6). The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR and high-resolution electrospray ionization mass spectra (HRESIMS) data. The absolute configuration of 1 was further established by single-crystal X-ray diffraction studies. Compounds 1–5 were evaluated for cytotoxicity towards CCRF-CEM human acute lymphatic leukemia cells, and it was found that 1 had an IC50 value of 0.46 µM.
Highlights
Marine organisms, especially sponges and microbes associated with them, are prolific producers of structurally diverse and bioactive natural products [1,2,3,4,5]
Sponge-associated fungi have produced many intriguing molecules reported with conspicuous pharmacological and biological properties, exemplified by antimicrobial [11,12,13], cytotoxic [13,14], anti-viral [15,16], antifungal [17], anti-inflammatory [18], and α-glucosidase inhibitory [19] activities
Mesophotic coral ecosystems (MCEs or “Twilight zone” coral reefs) range from 30 to 150 m deep and represent approximately 80% of potential coral reef habitats worldwide, but little is known about them compared with shallow reefs [20,21]
Summary
Especially sponges and microbes associated with them, are prolific producers of structurally diverse and bioactive natural products [1,2,3,4,5]. Mesophotic coral ecosystems (MCEs or “Twilight zone” coral reefs) range from 30 to 150 m deep and represent approximately 80% of potential coral reef habitats worldwide, but little is known about them compared with shallow reefs [20,21]. The organism first prioritized was a Cymostachys fungus that yielded a series of example, in the previous work, the organism first prioritized was a Cymostachys fungus new compounds, cymopolyphenols.
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