Abstract
One previously undescribed polyhydroxylated steroid, dysideafrondohexaol (1), together with four known ones, 5α-cholesta-7,22-diene-2α,3β,5α,6β,9α,11α,19-heptol-11,19-diacetate (2), 5α-cholesta-7-ene-2α,3β,5α,6β,9α,11α,19-heptol-11,19-diacetate (3), 5α,8α-cyclicobioxygen-6-vinyl-3β-cholesterol (4), and 5α,8α-cyclicobioxygen-6-vinyl-3β-cholesterol (5), were isolated from the Taiwanese sponge Dysidea aff. frondosa. Their structures were determined on the basis of spectroscopic data (1H- and 13C-NMR, COSY, HSQC, HMBC and NOESY), and HR-ESI-MS. In addition, the cytotoxicity of the isolates was evaluated on the MCF-7, Hep3B, and SC-M1 cell lines. Three constituents, compounds 1, 2 and 5 showed different sensitivities in inhibiting the growth of MCF-7 breast cancer cells, with IC50 values ranging from 7.9 to 22 μM, while compounds 3 and 4 did not show obvious effects. Among these isolates, 5α,8α-cyclicobioxygen-6-vinyl-3β-cholesterol (5) showed as most actively compound against the MCF-7, Hep3B, and SC-M1 cell lines with IC50 values of 7.9, 17.7, and 8.3 μM, respectively.
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