Abstract
Abstract Two new polyacetylenic compounds, callysponynes A (1) and B (2), were isolated from the marine sponge Callyspongia sp. The structures of the new metabolites were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Moreover, the absolute configuration of 1 was determined by Mosher’s method. Compounds 1 and 2 exhibited cytotoxic activity in vitro against MOLT-4, K-562, and HCT 116 cancer cell lines.
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