Abstract
The endophytic fungus Chaetomium sp. was separated from the medicinal plant Salvia officinalis growing in Egypt and cultivated on solid rice medium. Chemical investigation of the EtOAc extract yielded a new hydroperoxycochliodinol derivative (1) in addition to several known compounds, which included cochliodinol (2), isocochliodinol (3), chaetomin (4), and two simple indole derivatives (5, 6). The structure of the new compound was determined by comprehensive NMR studies including DEPT, COSY, HMQC, HMBC, and HR-MS. All compounds were tested for their cytotoxic activity against L5178Y cells. Compounds 1, 2, and 4 showed cytotoxic activity with EC50 values between 3.5–5.0 μg/mL, whereas compounds 3, 5, and 6 were inactive.
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