Abstract
Respiratory diseases, including pulmonary fibrosis, silicosis, and allergic pneumonia, can be caused by long-term exposure to dental prosthesis grinding dust. The extent of the toxicity and pathogenicity of exposure to PMMA dust, Vitallium dust, and dentin porcelain dust differs. The dust from grinding dental prosthesis made of these three materials was characterized in terms of morphology, particle size, and elemental composition. The adverse effects of different concentrations of grinding dust (50, 150, 300, 450, and 600 μg ml−l) on RAW264.7 macrophages were evaluated, including changes in cell morphology and the production of lactate dehydrogenase (LDH) and reactive oxygen species (ROS). The dust particles released by grinding dental prosthesis made of these materials had different morphologies, particle sizes, and elemental compositions. They also induced varying degrees of cytotoxicity in RAW264.7 macrophages. A possible cytotoxicity mechanism is the induction of lipid peroxidation and plasma membrane damage as the dust particles penetrate cells. Therefore, clinicians who regularly work with these materials should wear the appropriate personal protection equipment to minimize exposure and reduce the health risks caused by these particulates.
Highlights
Respiratory diseases, including pulmonary fibrosis, silicosis, and allergic pneumonia, can be caused by long-term exposure to dental prosthesis grinding dust
Epidemiological investigations indicated that the effects of dental prosthesis grinding dust on the respiratory system of oral care workers may be correlated with dust exposure time and the type of dust
The Vitallium group (c, d) consisted of particles arranged in a sheet with irregular edge morphology
Summary
Respiratory diseases, including pulmonary fibrosis, silicosis, and allergic pneumonia, can be caused by long-term exposure to dental prosthesis grinding dust. The adverse effects of different concentrations of grinding dust (50, 150, 300, 450, and 600 μg ml−l) on RAW264.7 macrophages were evaluated, including changes in cell morphology and the production of lactate dehydrogenase (LDH) and reactive oxygen species (ROS). The dust particles released by grinding dental prosthesis made of these materials had different morphologies, particle sizes, and elemental compositions. They induced varying degrees of cytotoxicity in RAW264.7 macrophages. Used prosthetic materials include PMMA, Vitallium, and porcelain, and the dust created from grinding them may pose various health hazards to oral care workers, such as pulmonary fibrosis, silicosis, allergic pneumonia, lung granuloma, asthma, and lung c ancer[5,6,7,8]. Wen et al reported that the toxicity of hydrogen peroxide (H2O2) was evaluated by detecting the levels of ROS and LDH in RAW264.7 c ells[21]
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