Abstract
1. 1. Perfusion of isolated frog hearts with phenazine methosulphate (PMS) at 0.3–1.0 mM caused a fall in amplitude and frequency of beat, and finally a cessation of contractile activity, together with widespread ultrastructural damage. 2. 2. Sarcolemma blebs were a characteristic feature of the damage. 3. 3. No protection was provided by mannitol (10–100 mM), Superoxide dismutase, catalase or a pH o of 6.6. 4. 4. Potassium ferricyanide (1–6 mM), an artificial electron acceptor, also caused ultrastructural damage. 5. 5. Comparisons are made with the oxygen paradox of mammalian heart, and the possible role of Ca 2+ fluxes and oxygen radicals in muscle damage are discussed.
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