Abstract
Aim: To investigate the cytotoxic effects of modified bioactive and antimicrobial gutta percha onthe fibroblast cells.Methods: The cytotoxic effects of modified bioactive and antimicrobial gutta percha on thefibroblast cells were investigated using Methylthiazol tetrazolium (MTT) assays at different times24, 48 and 72 hours.Results: there is no significant difference between controle and new modified gutta percha at first24 hrs. while with time at 48 and 72 hrs. there were significant difference.Conclusion: Bioactive bioglass BG45S5 and chitosan showed in vitro cytotoxic effects whenmixing with gutta percha in fibroblast cells as demonstrated by MTT assays, although toxic effectwas observed mostly as the same to control gutta percha.
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