Abstract
The aim of the present study was to evaluate the potential anticancer action of extracts prepared from german chamomile (Matricaria recutita L.)and pot marigold (Calendula officinalis L.) to human melanoma and epidermoid carcinoma cells. Sulforhodamine B assay was used to measure the cytotoxic activity of methanolic extracts from flowers of chamomile and marigold. The cytotoxic activity of extract of chamomile flowers on melanoma cells (IC50 value 40.7 μg/ml) was approximately twofold higher than on epidermoid carcinoma cells (IC50 value 71.4 μg/ml). In the present study, the anticancer action of extracts prepared from german chamomile flowers on human melanoma and non-melanoma skin cancer cells (SK-MEL-2 melanoma and KB epidermoid carcinoma cells) is described for the first time.
Highlights
The incidence of both non-melanoma and melanoma skin cancers is an increasing problem for health care services worldwide
We evaluated the potential anticancer action of extracts prepared from chamomile and marigold to different cancer cells: human melanoma and epidermoid carcinoma cells
The strongest anticancer effect was found with the methanol extract of chamomile flowers against SK-MEL-2 cells (IC50 40.68 ± 2.92 μg/ml)
Summary
The incidence of both non-melanoma and melanoma skin cancers is an increasing problem for health care services worldwide. The infusion has been used for relieving gastrointestinal disorders All these medicinal properties have made chamomile increasingly popular today, and for example, chamomile tea is globally consumed even more than one million cups per day (Srivastava & Gupta, 2009). Chamomile is applicable for preventing and treating e.g. breast, ovarian and prostate cancer (Kozak, Sobczak, & Żukiewicz-Sobczak, 2016). The extracts of chamomile flowers have been shown to inhibit cell growth and to induce apoptosis in some human cancer cell lines (i.e. prostate, cervix, colon, breast cancer cells, and fibrosarcoma cells), these effects were exerted at rather high concentrations (IC50 in the range of more than 100 μg/ml) (Srivastava & Gupta, 2009; Matić et al, 2013). No studies have been published reporting the activity of chamomile extracts on human skin cancer cells
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