Cytotoxic effect of binar cisplatin immunoconjugate.

Abstract

Increasing the effeciency of antitumoral therapy is connected, to a considerable degree, with creating and using perspective forms of antitumor preparations of a purposeful action. Platinum preparations relate to the effective group of cytostatic compounds, inhibitors of tumor and leukemic cell proliferation. Also, the platinum drugs as a majority of other antitumor cytostatics, possess a low action selectivity having a side toxic effect on the blood system, kidneys and other organs. In this connection it seems expedient to create transport forms of platinum drugs, and in particular, the known cytostatic compound of platinum/cis-dichlorinediaminoplatinum (cis-DDP) with using monoclonal antibodies. The aim of the present investigation was studying cytotoxic activity ofbinar form of cisplatin immunocon-jugate obtained on the basis of special technology (know-how). As a vector in the given case the monoclonal antibodies specific to the mice erythroblast antigens were used.KeywordsLeukemic CellCytotoxic EffectSpecial TechnologySide Toxic EffectTrypan Blue StainingThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.