Abstract
Eleven compounds including one new cytochalasin derivative, scoparasin C (1), four cytochalasins (2–5), four pimarane diterpenes (6–9) and two chromene derivatives (10 and 11) were obtained from a culture broth of Eutypella scoparia PSU-H267 which was isolated from a leaf of Hevea brasiliensis. Their structures were determined by spectroscopic evidence. For compounds 2, 3 and 5, the structures were confirmed by single-crystal X-ray diffraction crystallography. Compounds 1, 3, 4 and 7 were strongly active against Vero cell lines with IC50 values of 1.19, 0.04, 1.01 and 2.50μM, respectively. Only compound 3 displayed potent cytotoxic activity towards KB-oral cavity cancer cell lines with the IC50 value of 2.46μM.
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