Abstract
A new compound and seven known compounds were isolated from Murraya tetramera Huang for the first time, and they were identified with NMR and MS spectral analysis. It was confirmed that the new compound was 10-methoxy-7-methyl-2H-benzo[g]chromen-2-one (3) and the others were β-eudesmol (1), trans-3β-(1-hydroxy-1-methylethyl)-8aβ-methyl-5-methylenedecalin-2-one (2), 5,7-dimethoxy-8-[(Z)-3'-methyl-butan-1',3'-dienyl]coumarin (4), 7-geranyloxy-6-methoxycoumarin (5), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumarin (6), murrangatin acetate (7) and toddalenone (8). Furthermore, the cytotoxic activity against human lung adenocarcinoma (A549), human hepatocellular carcinoma cells (SMMC-7721), human bladder tumor cells (EJ), human cervical carcinoma cells (HeLa), and human B-lineage acute lymphoblastic leukemia 1 cells (BALL-1) was evaluated for all compounds. It was found that five of them displayed various degrees of cytotoxicity against different testing targets. Compound 1 showed significant cytotoxic activity against the five cell lines (A549, SMMC-7721, EJ, Hela and BALL-1). Compounds 2 and 5 showed significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1). Compound 4 showed significant cytotoxicity against three cell lines (A549, EJ and BALL-1). However, compound 3 only showed fair cytotoxicity against the BALL-1 cell line. The structure-active relationships were investigated as well. These active compounds might be potential lead compounds for the treatment of cancer.
Highlights
Cancer is one of the most common diseases that threaten peoples’ health
A new compound and seven known compounds were isolated from the M. tetramera for the first time
The cytotoxicity of compounds 1–8 was evaluated against A549, SMMC-7721, EJ, human cervical carcinoma cells (HeLa) and B-lineage acute lymphoblastic leukemia 1 cells (BALL-1) cancer cell lines using the Cell Counting Kit (CCK)-8 method
Summary
Cancer is one of the most common diseases that threaten peoples’ health. much effort has been invested to develop effective treatments. TCM have been one of the most important sources for seeking new leading compounds that possess significant cytotoxicity [7,8,9]. M. tetramera is widely distributed in the Chinese provinces of Guangxi and Yunnan. It has been used as a folk TCM for the treatment of colds, coughs, asthma, stomach disorders, rheumatism, pruritus and eczema [11,17]. As a result a new coumarin and seven known compounds were isolated from M. tetramera for the first time and all the compounds were evaluated in vitro against the A549, SMMC-7721, EJ, HeLa and BALL-1 tumor cell lines. The results indicated that some of these compounds have significant cytotoxic activities against the five tested human cancer cell lines
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