Abstract
Chemical purification of the ethyl acetate extract from the seeds of Sophora alopecuroides yielded a new natural product, ethyl 2-(4-hydroxybenzyl) malic acid (1), along with 7 known compounds, methyl eucomate (2), eucomic acid (3), piscidic acid (4) and ethyl 2-(4-hydroxybenzyl) tartrate (5), butein-4'-O-β-D-glucopyranoside (6), iso-liquiritigenin (7), and butein (8). The structure of 1 was determined by spectroscopic analyses including extensive 1D (1H NMR, 13C NMR) and 2D NMR spectra (COSY, HSQC and HMBC) as well as MS data. All compounds were evaluated for their cytotoxic activities against hepato-cellular carcinoma (HCC) cell lines, HepG2 andHep3B. Compound 8 significantly inhibited the cancer cell growth in a concentration-dependent manner.
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