Abstract
A new cytotoxic anthraquinone glucoside, pulmatin, 1,8-dihydroxy-3-methyl-anthraquinone-1- O-β- d-glucoside, and its congeners, chrysophanein and physcionin, have been isolated as minor components from the root of Rheum pulmatum, an Indonesian Jamu (medicinal plant) known as ‘kelembak’ by recycling high performance liquid chromatography (R-HPLC). These anthraquinone glycosides exhibited moderate cytotoxic activity against several types of carcinoma cells. Their structures were established by means of spectroscopic methods, in particular, the NMR data.
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