Abstract
Quercetin is the main flavonoid in diet with a potential in the treatment of cancer, cardiovascular, and neurodegenerative diseases. Due to its specific planar chemical structure, quercetin readily forms chelates with metal ions. Complexes of bioactive compounds and metal ions such as lanthanum often show strong cytotoxic and antitumour properties. The aim of this study was to compare the genotoxic effects of the quercetin/lanthanum complex on human cervical carcinoma cells with compare it to the effects of free ligands, quercetin, and lanthanum alone. The quercetin/lanthanum complex showed considerable cytotoxicity in the concentration range of (100 to 1000) mmol mL-1 and exposure time of three hours. The complex also induced a dose-dependent pro-oxidative effects and the formation of single-strand and double-strand DNA breaks. Although we obtained promising results on the cell level, future experiments should answer whether the quercetin/lanthanum complex is cancer-specific and stable enough in physiological conditions to make a potential new antitumour drug.
Highlights
Quercetin is the main flavonoid in diet with a potential in the treatment of cancer, cardiovascular, and neurodegenerative diseases
Lanthanum complexed with bioactive compounds from plants has shown even stronger cytotoxic effect than when administered alone [4], suggesting that electron transfer and oxidative stress are responsible for the cytotoxic effect
We wanted to see if the lanthanum-quercetin complex had a stronger cytotoxic, prooxidative, and genotoxic effects on human cervical carcinoma cell line (HeLa) than lanthanum and quercetin alone
Summary
Quercetin is the main flavonoid in diet with a potential in the treatment of cancer, cardiovascular, and neurodegenerative diseases. Wang et al [1] analysed a lanthanum-naringenin Schiff-base complex and found that the ligands were coordinated to the lanthanum ion through deprotonated hydroxyl groups This complex bound directly to calf-thymus DNA, probably through intercalation, while the same concentrations caused a strong cytotoxic effect on human leukaemia and lung adenocarcinoma cells. We wanted to see if the lanthanum-quercetin complex had a stronger cytotoxic, prooxidative, and genotoxic effects on human cervical carcinoma cell line (HeLa) than lanthanum and quercetin alone. In case it did, lower doses of the complex would have the same biological effect on the tumour cells, without the side effects associated with high drug concentrations
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