Abstract
A combined treatment with warfarin (W) and the alkylating agent nitrogen mustard (HN 2) was performed from the human heteroploid cell line (EUE). Warfarin was added to the cultures and after 24 hr contact the W treatment was repeated together with different HN 2 doses. Cytotoxicity was measured as percentage reduction in cell density and the chromosomal effects were evaluated by determining the frequency of chromosomal aberrations. As compared to EUE cultures treated only with HN 2 a significant increase in the toxicity values and in the amount of cytogenetic damage was found in cultures submitted to a combined treatment of HN 2 and W, which does not display toxicity in the experimental conditions utilized.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
