Abstract
The basic goal of this study was to synthesize zinc oxide nanoparticles using the Chelidonium majus extract and asses their cytotoxic and antimicrobial properties. The synthesized ZnO NPs were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The aforementioned methods confirmed that the size of synthesized ZnO nanoparticles was at the range of 10 nm. The antimicrobial activity of ZnO nanoparticles synthesized using the Ch. majus extract was tested against standard strains of bacteria (Staphylococcus aureus NCTC 4163, Pseudomonas aeruginosa NCTC 6749, Escherichia coli ATCC 25922), yeast (Candida albicans ATCC 10231), filamentous fungi (molds: Aspergillus niger ATCC 16404, dermatophytes: Trichophyton rubrum ATCC 28188), clinical strains of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus) and yeast (Candida albicans). The study showed that zinc oxide nanoparticles were excellent antimicrobial agents. What is more, biologically synthesized ZnO nanoparticles demonstrate high efficiency in treatment of human non-small cell lung cancer A549.
Highlights
Nanotechnology belongs to the fastest growing technologies in the world (Gao et al 2013, Rico and White 2014)
Antimicrobial activity of biosynthesized Zinc oxide (ZnO) nanoparticles using the Ch. majus extract was tested against standard strains of bacteria (Staphylococcus aureus NCTC 4163, Pseudomonas aeruginosa NCTC 6749, Escherichia coli ATCC 25922), yeast (Candida albicans ATCC 10231), filamentous fungi, clinical strains of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus) and yeast (Candida albicans)
The presence of ZnO nanoparticles synthesized biologically with the use of the extract from Ch. majus was confirmed by the maximum absorption of about 310 nm, which is a characteristic band of pure ZnO (Wahab et al 2014)
Summary
Nanotechnology belongs to the fastest growing technologies in the world (Gao et al 2013, Rico and White 2014). Nanoparticles are widely applied in medicine, the environment, and industry. A highly significant and promising inorganic material is Zinc oxide (ZnO). Zinc oxide nanoparticles belong to the group of multifunctional inorganic nanoparticles. These metal nanoparticles have found a wide use in numerous industrial areas, such as solar cells, UV light-emitting devices, gas sensors, photocatalysts, pharmaceutical and cosmetic industries (Sangeetha et al 2011). ZnO nanoparticles have been studied for possible applications in medicine. They exhibit a high degree of cancer cell selectivity and they are able to surpass the therapeutic indices of some commonly used chemotherapeutic agents (Hanley et al 2008). There are various procedures for preparing ZnO nanoparticles, such as the chemical vapor, solvothermal, high temperature, direct precipitation, sol-gel and hydrothermal method (Suresh et al 2015)
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