Abstract
Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 μg/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 ± 1.24-134.79 ± 0.01 μg/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, β-glucans, and polyphenolic compounds.
Highlights
G rowing research interest in mushrooms have shown that edible mushrooms are not interesting only as tasty food rich in the important nutrients, and as a source of primary and secondary metabolites with various biological activities.[1]
The golden chanterelle, Cantharellus cibarius Fr. (Cantarellaceae), is an edible mushroom, yellow to orange with fruity and mildly peppery taste
This research covered different biological activities of C. cibarius extracts with an accent on anti-Helicobacter pylori activity and cytotoxicity against N87 gastric carcinoma cells
Summary
(Cantarellaceae), is an edible mushroom, yellow to orange with fruity and mildly peppery taste. G rowing research interest in mushrooms have shown that edible mushrooms are not interesting only as tasty food rich in the important nutrients, and as a source of primary and secondary metabolites with various biological activities.[1] The golden chanterelle, Cantharellus cibarius Fr. It grows in deciduous and coniferous forests, in groups. This research covered different biological activities of C. cibarius extracts with an accent on anti-Helicobacter pylori activity and cytotoxicity against N87 gastric carcinoma cells.
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