Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates

Mayada El-Ayouty,Reda Abdelhameed,Safwat Ahmed,Eman Habib,Hashim Hassanean

doi:10.21608/rpbs.2021.90767.1111

Abstract

Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates

Highlights

Marine life forms, comprising more than half of the entire worldwide organisms, offer an important source of possibly novel active compounds
The potential invitro cytotoxicity of the soft coral S. glaucum extract and three of the isolated compounds were measured against HepG2 and MCF7 and the extract was tested against the protozoan parasite Leishmania donovani, using pentamidine and amphotericin B as controls
The isolated compounds were identified as: Compound 1 was identified as palmitic acid (Figure 1) (Di Pietro et al, 2020), as molecular formula was determined to be C16H32O2 by El-mass spectrum as the molecular ion peak appeared at m/z 256.08 [M]+. 1H-NMR (CD3OD-CDCl3): δ 2.32 (2H, m, H-2), 1.63 (2H, m, H-3), 1.27 (24H, s, H-4: H-15), 0.84 (3H, t, J=8.0, H-16). 13C-NMR (CD3OD-CDCl3): δ 173.8 (C-1), 34.3 (C-2), 31.8 (C-3), 22.6-29.6 (C-4: C-15), 14.0 (C-16)

Summary

Introduction

Marine life forms, comprising more than half of the entire worldwide organisms, offer an important source of possibly novel active compounds. Soft corals comprising an important group of marine organisms. There are about 35 species belonging to the soft coral genus. Sarcophyton, and they are hard to be distinguished (Verseveldt, 1982). Many secondary metabolites isolated from soft corals have been proved to possess many different biological activities such as anti-microbial, anti-fungal, anti-tumor, anti-viral and antiinflammatory (Wei et al, 2013). In our study we are trying to discover biologically active compounds from Egyptian natural products, our group in focused on the isolation of the active compounds from the soft coral S. glaucum, and identification of the isolated compounds using different spectroscopic techniques. The potential invitro cytotoxicity of the soft coral S. glaucum extract and three of the isolated compounds were measured against HepG2 and MCF7 and the extract was tested against the protozoan parasite Leishmania donovani, using pentamidine and amphotericin B as controls

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Conclusion