Abstract
Two new natural cycloartanes, tubiferolide methyl ester ( 1 ) and tubiferaoctanolide ( 2 ), together with the known coronalolide ( 3 ) and coronalolide methyl ester ( 4 ) have been isolated from leaves and twigs of Gardenia tubifera. In addition, a new flavone 5,3′,5′-trihydroxy-7,4′-dimethoxyflavone ( 5 ), five known flavones 6– 10 and hexacosyl 4′-hydroxy- trans-cinnamate ( 11 ) were also obtained from the same source. The structures were assigned on the basis of spectroscopic methods. Compounds 3 , 7 , 9 , and 10 showed significant cytotoxic activities only in P-388 cell line. Compound 1 was cytotoxic against P-388, KB, Col-2 and Lu-1, while 4 was active in P-388 and BCA-1. Compounds 3 and 4 displayed significant anti-HIV activities in the HIV-1RT assay; compound 7 showed moderate activity in this assay. Compounds 5– 10 were also found to be active in the ΔTat/RevMC 99 syncytium assay.
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