Abstract
A cytotoxic agent which inhibits the division of HeLa cells at metaphase stage was isolated from Thujopsis dolabrata (L. fil.) SIEB. et ZUCC. and identified as desoxypodophyllotoxin. Three substances, desoxypodophillic acid, desoxypicropodophyllin and β-peltatin-B-methylether were isolated from the recrystallization mother liquor of desoxypodophyllotoxin after treatment with alkali. Desoxypodophyllotoxin was found to be almost exclusively contained in the leaf and bark of this tree and only in minute quantity in its wood. It was also shown to be contained in T. dolabrata var. hondae MAKINO, Juniperus rigida SIEB. et ZUCC. and J. chinensis L. by thin-layer chromatography and cytotoxicity.
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