Abstract
Zinc Oxide (ZnO) nanoparticle was synthesized using rhizome extracts of Zingiber officinale for in-vitro anti-cancer study. The characterization of nanoparticle was confirmed using ultraviolet spectroscopy and Fourier Transfer Infrared Spectroscopy (FTIR). The ZGNPE characterization also used the UV-Vis Spectrophotometer spectrum technique to measure the structural characterization of nanoparticles by determine the absorbance measurement. Cytotoxic activity of myelogenous leukemia cells (K562) and normal human embryonic Kidney (HEK293T) cells were performed by MTT assay. Treated with ZnO nanoparticle with Zingiber officinale extracts (ZGNPE) showed significant inhibition on the cancer cells whereas in normal cell showed insignificant toxicity. Thus, ZGNPE may be used as chemotherapy drug and an enormous medical application with less toxicity in future. Further mechanistic studies are in progress.
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