Abstract
The cytotoxic activity of 22 methanol extracts of fresh fruiting bodies of the Tricholomatales order was evaluated with two murine cancer cell lines (L1210 and 3LL). The 8 extracts that inhibited the growth of at least one murine cancer cell line were then evaluated with 4 human cancer cell lines (K-562, U251, DU145, MCF7). Four of them had significant cytotoxic activity (IC 50 =20 ?g/ml) against at least one human cancer cell line. Lepista inversa, with an IC 50 = 20 ?g/ml against the 4 human cancer cell lines tested and an activity either equal to or greater than that of a bark extract from Taxus baccata L., used as positive control, appeared to be the most promising species.
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